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The extent to which the available information supports the hypothesis that a substance causes an effect in humans. For example, factors which determine the weight-of-evidence that a chemical poses a hazard to humans include the number of tissue sites affected by the agent; the number of animal species, strains, sexes, relationship, statistical significance in the occurrence of the adverse effect in treated subjects compared to untreated controls; and the timing of the occurrence of adverse effect.

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Deel van toespraak: noun
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Industrie/Domein: Pollution control
Category: Air pollution
Company: ARB
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